Vaniqa - Review Of What Vaniqa Hair Inhibitor Medication Does
Vaniqa is a prescription cream applied to the skin for the reduction of unwanted facial hair in women ages 12 and older. For unknown reasons, Vaniqa does not work for everyone.
You'll have to get a prescription from your doctor. Some insurance policies do not cover Vaniqa.
Effectiveness: About 58% of women who tried Vaniqa prescription medication in clinical trials had improvement. The other 42% had no improvement.
Vaniqa prescription medication is not a depilatory, but rather appears to retard hair growth to improve the condition and the appearance of some consumers. You will likely need to continue using a hair removal method (e.g., shaving, plucking) in conjunction with Vaniqa. It will usually take 2 months of treatment before you see if it works or not. If you stop taking Vaniqa, your hair may come back to previous levels within 2 months after stopping.
The active ingredient in Vaniqa prescription medication is eflornithine hydrochloride. It inhibits an enzyme that affects hair growth, called ornithine decarboxylase (ODC). Clinical data indicates that taking an oral version of the drug can affect hair growth.
Vaniqa should not be used:
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By men. It has not been tested on males.
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By women who are pregnant or nursing, because Vaniqa has not been tested to see if it causes birth defects and miscarriages in humans
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Anywhere except on the face and chin.
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In the eyes, nose, mouth, or vagina.
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If you have severe acne or broken skin.
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Background To Vaniqa Prescription Medication
Hair growth cells and cancer cells share some interesting characteristics: rapidly dividing with multiple potentials for differentiation. This is part of the reason chemotherapy and radiation can result in hair loss: they disrupt the same kinds of cellular activity. [1] It has been theorized that some cancer drugs may be used to induce a controlled amount of hair loss or reduction. Vaniqa's active ingredient, eflornithine hydrochloride, has been observed to result in antitumor activity. [2] It is the first commercially-available topical preparation to come out of this sort of research.
Vaniqa became available on July 31, 2000. Originally made by Bristol-Myers Squibb in a partnership with Gillette, it is now a separate company under the name Women First Healthcare.
Clinical data on Vaniqa Prescription Medication
Eflornithine hydrochloride inhibits an enzyme which has been observed to affect hair growth in rats [3]. Regulation of this enzyme, called ornithine decarboxylase (ODC), was later shown to reduce hair growth in mice [4] and sheep [5]. Recent studies suggest observations in certain types of mice may have parallels in humans. [6, 7]
This drug has been found to be an astonishingly effective cure for some types of African "sleeping sickness," even able to cause a rapid and complete recovery in comatose patients. [8] Clinical reports show that taking it orally to treat sleeping sickness can induce hair loss as a side effect. [9]
One large published study on safety found the product rarely caused significant side effects such as acne, follicle irritation, itching or dryness. [10]. This corroborates unpublished data submitted to FDA showing about 2% of subjects discontinued use due to adverse reactions. [11]
Unpublished efficacy data submitted to FDA observed about 58% of women using it on facial hair had improvement. [11] This study suggests it may be particularly effective in postmenopausal women.
Proof of how hard it is to judge effectiveness
Perhaps the most striking result was how many women in the control group (who used cream with no active ingredient) were observed to have less hair. Of 201 patients, over one-third who used a placebo were assessed by physicians as either “improved” or “marked improvement.” [11]
This huge number of “false positives” means two things for consumers seeking hair removal:
It's really hard to tell if a new hair removal product is effective or not, especially based on the personal experiences of just a few people.
It's really easy for quacks to exploit this difficulty and make overblown claims about products they promote.
That's why you should rely on large-scale controlled studies to determine if a hair removal product is effective.